Getting the most from capsuled medications and supplements

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When I first started with kratom, at the very beginning, I tried capsules and was rewarded with no burn; I thought it was bunk. Trying powder and perfecting toss n wash rid me of that notion.

So depending on the taste, if it's bad, like akuamma seed extract, or if the consistency is wrong, like maca powder which is too sticky to toss n wash (tastes really good, but I hardly make shakes or smoothies, and it doesn't mix good with water/juice/milk) I use Blate Papes oblates.

But that got me thinking... am I getting the most out of my meds n supps which are capsuled? Just throwing money away on ginseng, mushroom extract, even the Zupoo 15 day gut cleanse (for the remaining 5 or 6 days I'ma open them and t&w)? I was phasing out the ginseng and mushies since I did not notice any difference. Will open them too and t&w, hope they taste ok.
My time-release Cymbalta does dissolve and is effective, as is the L-theanine 200mg capsules.

Anyone else have experience with capsule working/not working?